“Long-range regulation during development and evolution”. Denis Duboule

Friday, November 7, 2014

The formation of digits during development is a high regulated process coordinates by the Hoxd genes. By analyzing the chromosome conformation and Hox transcriptional regulation during the process,…

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“Mechanisms for programming cell fate”. Kenneth Zaret

Friday, November 7, 2014

The concept that it is possible to reprogram the cell fate for therapeutic purpose is one of the hottest field of the last years. Kenneth Zaret is investigating…

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“C/EBPa induced immune cell transdifferentiation reveals two complementary macrophage enhancer pathways during hematopoiesis”. Chris Van Oevelen

Thursday, November 6, 2014

It is known that over expression of one single transcription factor, C/EBPa, is sufficient to convert B cells into macrophages thus regulating the transdifferentiation towards different lineages. However,…

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“The mRNA binding protein AUF1 controls skeletal muscle stem cell fate, linking AUF1 mutation to the development of limb girdle muscular dystrophy”. Robert J. Schneider

Thursday, November 6, 2014

AU-rich elements (AREs) are known to regulate the mRNA stability and about the 16% of human mRNAs contain this element. The sequence is recognized by specific ARE binding…

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“Oncogenes properties of the RNA-binding protein UNR: targets in melanoma”. Laurence Wurth

Thursday, November 6, 2014

RNA binding proteins are multifunctional factors that have a key role in the regulation of gene expression. Among them, Upstream of N-Ras (UNR) seems to be involved in…

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“Widespread intron retention in mammals functionally tunes tanscriptomes”. Ulrich Braunschweig

Thursday, November 6, 2014

Intron retention (IR) is the least well understood class of alternative splicing (AS) of precursor RNAs. Despite it represents the least prevalent form of AS in animals, it…

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“A novel role for the DYRK1A protein kinase as a chromatin-associated transcriptional regulator”. Chiara Di Vona

Thursday, November 6, 2014

Kinases are known to regulate gene expression influencing transcription factors and co-regulators; however, recently it is emerging a new role of these enzymes also in the dynamic of…

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“The role of architectural proteins in the three-dimensional organization of the chromatin”. Victor Corces

Thursday, November 6, 2014

If we compare the size of the complexes that architectural proteins form on the genome, we could define high occupied regions that are enriched at borders of topologically…

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“Lox2 oxidizes methylated TAF10 and controls neural progenitos specification”. Sandra Peir├│

Thursday, November 6, 2014

Despite the post-translational modification of proteins are mainly considered uncontrolled phenomenon, active enzymes regulate phosphorylation, methylation and oxidation of proteins. Important oxidation processes seem to be crucial for…

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“Targeted and genome-wide views into the mechanisms of transcription and it’s regulation in living cells”. John T.Lis

Thursday, November 6, 2014

How do cells regulate gene transcription upon a stress? At the Cornell University, Jhon Lis is trying to answer to this question. Using the heat shock response model…

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