“Investigating a novel role for senescence-associated stem cell gene expression”. Mekayla Storer
During senescence, cells undergo a proliferative arrest that seems to induce a tumorigenic effect on the neighbouring cells through secretion of specific molecules. The identification of senescence-related genes reveals that some of these are also stem cell-related genes. In vivo transplantation of senescent cells suggests that their tumor formation role could be played by altering the endogenous stem cell fate.